Hideaki Nakamura Selected Research

pirarubicin

1/2020	[Development of Tumor-targeting Antitumor Agents Based on Polymer Effect].
1/2020	Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization.
1/2019	Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.
5/2016	[Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect].
2/2016	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases.
2/2015	Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.
1/2014	Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hideaki Nakamura Research Topics

Disease

43	Neoplasms (Cancer) 01/2022 - 02/2002
6	Hypoxia (Hypoxemia) 01/2022 - 04/2007
5	Body Weight (Weight, Body) 08/2022 - 01/2002
5	Carcinogenesis 12/2013 - 01/2002
4	Carcinoma (Carcinomatosis) 06/2010 - 07/2002
4	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2010 - 06/2002
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 03/2022 - 12/2013
3	Pancreatic Neoplasms (Pancreatic Cancer) 05/2020 - 07/2002
3	Colonic Neoplasms (Colon Cancer) 09/2017 - 12/2013
3	Squamous Cell Carcinoma of Head and Neck 01/2010 - 09/2008
2	Inflammation (Inflammations) 08/2022 - 04/2017
2	Chronic Granulomatous Disease 08/2022 - 06/2012
2	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2015
2	Colitis 08/2014 - 12/2013
2	Reperfusion Injury 12/2011 - 12/2011
2	Lymphatic Metastasis 04/2007 - 07/2002
2	Necrosis 03/2002 - 02/2002
1	Pneumonia (Pneumonitis) 08/2022
1	Cholangitis 01/2022
1	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2021
1	Hepatomegaly 05/2019

Drug/Important Bio-Agent (IBA)

15	Pharmaceutical PreparationsIBA 10/2021 - 03/2011
8	hydroxypropyl methacrylateIBA 10/2021 - 02/2013
7	N-(2-hydroxypropyl)methacrylamideIBA 10/2021 - 01/2014
7	pirarubicinIBA 01/2020 - 01/2014
5	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 08/2022 - 03/2008
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
5	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 03/2011
5	zinc protoporphyrinIBA 01/2020 - 02/2013
5	PolymersIBA 01/2020 - 11/2015
5	Therapeutic UsesIBA 09/2017 - 01/2013
4	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2022 - 03/2008
4	HydrazonesIBA 01/2020 - 01/2014
4	Biological ProductsIBA 01/2020 - 01/2015
4	Cisplatin (Platino)FDA LinkGeneric 02/2016 - 09/2008
3	EnzymesIBA 08/2022 - 03/2008
3	Styrene (Styrol)IBA 03/2022 - 08/2014
3	maleic acid (maleate)IBA 03/2022 - 08/2014
3	Carbon MonoxideIBA 03/2022 - 03/2012
3	Messenger RNA (mRNA)IBA 01/2022 - 09/2008
3	liposomal doxorubicin (Doxil)FDA Link 10/2021 - 11/2015
3	AcidsIBA 10/2021 - 01/2014
3	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2020 - 01/2014
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 02/2002
3	CytokinesIBA 04/2017 - 12/2013
3	MicellesIBA 02/2016 - 02/2013
3	DuxonIBA 11/2015 - 02/2013
3	Heme Oxygenase-1IBA 03/2012 - 02/2008
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2010 - 04/2007
2	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 08/2022 - 03/2008
2	Liposomes (Liposome)IBA 05/2020 - 11/2015
2	AnthracyclinesIBA 01/2020 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 11/2013
2	methacrylamideIBA 01/2020 - 05/2016
2	Singlet OxygenIBA 01/2020 - 02/2013
2	human S-nitrosoalbuminIBA 09/2017 - 11/2015
2	Evans Blue (Blue, Evans)FDA Link 11/2015 - 03/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2014 - 08/2014
2	Nitroglycerin (Dynamite)FDA LinkGeneric 10/2014 - 01/2013
2	Angiotensin IIIBA 10/2014 - 01/2013
2	Dextran SulfateIBA 08/2014 - 12/2013
2	SolutionsIBA 02/2013 - 03/2008
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 06/2012 - 04/2012
2	Hemin (Panhematin)FDA Link 03/2012 - 12/2011
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2012 - 02/2008
2	PlatinumIBA 01/2010 - 09/2008
2	Telomerase (Telomerase Reverse Transcriptase)IBA 03/2006 - 06/2002
2	AntioxidantsIBA 01/2005 - 04/2002
1	NADP (NADPH)IBA 08/2022
1	GlucansIBA 08/2022
1	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022
1	Heme (Haem)IBA 01/2022
1	GuanineIBA 01/2022
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2022
1	PlasticsIBA 01/2022
1	BradykininIBA 10/2021
1	1-dodecylpyridoxal (PLD)IBA 10/2021
1	NucleotidesIBA 01/2021
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2021
1	isothiocyanic acidIBA 05/2020
1	Bromelains (Bromelain)IBA 05/2020
1	Polyethylene (Polythene)IBA 05/2020
1	GelatinIBA 05/2020
1	Fluorescein (Funduscein)FDA LinkGeneric 05/2020
1	fluorescein isothiocyanate dextranIBA 05/2020
1	Photosensitizing Agents (Photosensitizers)IBA 01/2020
1	Estrogen ReceptorsIBA 01/2020
1	Free RadicalsIBA 01/2020
1	CholesterolIBA 05/2019
1	CyclodextrinsIBA 05/2019

Therapy/Procedure

8	Therapeutics 01/2021 - 03/2008
2	Photochemotherapy (Photodynamic Therapy) 11/2015 - 01/2015
2	Oral Administration 12/2013 - 10/2011
2	Drug Therapy (Chemotherapy) 01/2010 - 09/2008
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 08/2022
1	Enzyme Replacement Therapy 08/2022
1	Stents 01/2022
1	Intravenous Administration 05/2020